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Shares of CTI BioPharma Corp have dropped sharply on news that the US FDA has placed a partial hold on pacritinib, an oral tyrosine kinase inhibitor (TKI) with activity against JAK2 and FLT3 mutations, which is being developed as a treatment for myelofibrosis and is partnered with Baxalta. A rolling NDA submission was completed in January this year.
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