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CRISPR 'Not Good Enough' For CAR-T Product Manufacturing

This article was originally published in Scrip

Executive Summary

CRISPR techniques are just not accurate enough for the precision gene editing required for the scalable manufacture of CAR-T therapies, according to Cellectis CEO Andre Choulika. Cellectis has an 'off the shelf' CAR-T product for the treatment of leukemia which targets the CD19 antigen, the same target other companies in the CAR-T space such as Novartis, Kite Pharma and Juno Therapeutics are focused on.

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